Associations between endogenous sex hormones and multisite chronic musculoskeletal pain.

ABSTRACT:

Background

Sex-differences in pain perception have been documented; however, the role of sex hormones in chronic musculoskeletal pain (CMP) remains unclear. Therefore, this study investigated whether sex hormones and sex hormone-binding globulin (SHBG) are associated with CMP.

Methods

We utilised data from the UK Biobank (n=357 424; females: 51.6%; white: 95.2%). Serum concentrations of oestradiol (E2), testosterone (T), and SHBG were measured at baseline. Chronic pain (≥3 months) in the neck/shoulder, back, hip, knee, or 'all over the body' was assessed at baseline and three follow-ups. Mixed-effects multinomial/logistic regression models were used.

Results

In multivariable analyses, greater concentrations of T and T/SHBG were associated with a lower number of CMP si

SUBMITTER: Kifle ZD 

PROVIDER: S-EPMC11867097 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature