Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Mild depression lacks a consistent definition across diagnostic criteria and rating scales, posing challenges to standardizing treatment strategies. International guidelines predominantly recommend psychotherapy as the first-line treatment for mild depression, while the use of antidepressants remains contentious. Supplements such as omega-3 fatty acids, St. John's Wort, and magnesium have garnered attention as alternative therapeutic options for depression. This systematic review aims to assess the efficacy of pharmacological interventions, including supplements, in the treatment of mild depression.

Methods

Comprehensive searches were performed in PubMed and Embase through November 2024 to identify randomized controlled trials (RCTs) investigating pharmacotherapy

SUBMITTER: Urata M 

PROVIDER: S-EPMC11867163 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature