Evaluation of parameters extracted from tissue residue functions in dynamic susceptibility contrast MRI: Healthy volunteers examined during normal breathing and spontaneous hyperventilation.

ABSTRACT: Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is the most common MRI method in clinical environments for assessment of perfusion-related parameters. In this study, special emphasis was placed on the shape of the tissue residue function under different physiological conditions. DSC-MRI-based parameters assumed to reflect arterial delay and cerebral oxygen extraction were obtained by deconvolution of tissue and arterial contrast-agent concentration time curves. The established mean transit time (MTT) estimate was supplemented by biophysical modelling for extraction of the oxygen extraction capacity, quantified in terms of an apparent oxygen extraction fraction (AOEF) index. Eight healthy volunteers were examined during normal breathing and spontaneous hyperventilation.

SUBMITTER: Wirestam R 

PROVIDER: S-EPMC11867289 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature