Prophylactic antibiotics in laparoscopic cholecystectomy: Reducing postoperative infection risk-A meta-analysis and trial sequential analysis.

ABSTRACT:

Background

The impact of prophylactic antibiotics on postoperative infection following laparoscopic cholecystectomy remains controversial. This meta-analysis and trial sequential analysis aims to assess the efficacy of prophylactic antibiotics in reducing the risk of postoperative infection following laparoscopic cholecystectomy.

Methods

Multiple databases including PubMed, Cochrane Library, EMBASE, and Web of Science were systematically searched to identify relevant randomized controlled trials (RCTs) published from inception to January 23, 2024. This study analyzed endpoints such as infection complications (IC) and surgical site infections (SSI). RCTs comparing prophylactic antibiotics versus placebo or no treatment in patients undergoing laparoscopic cholecystectomy were

SUBMITTER: Wang S 

PROVIDER: S-EPMC11867292 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature