Pharmacological interventions for addressing pediatric and adolescent obesity: A systematic review and network meta-analysis.

ABSTRACT:

Background

Obesity significantly impacts the health outcomes of children and adolescents, necessitating a comprehensive study to evaluate the effects of various anti-obesity medications (AOMs) on weight-related and metabolic outcomes.

Methods

PubMed, EMBASE, and CENTRAL were searched for studies published up to January 3, 2024. We performed a network meta-analysis on randomized clinical trials that compared various treatments for pediatric and adolescent obesity, such as phentermine/topiramate, semaglutide, exenatide, liraglutide, topiramate, metformin, fluoxetine, metformin/fluoxetine, sibutramine, and orlistat. The study evaluated body mass index (BMI), BMI percentage change, weight, BMI-SDS, waist circumference, metabolic, anthropometric, and safety outcomes.

Results</

SUBMITTER: Yang S 

PROVIDER: S-EPMC11867386 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature