Aligning cellular and molecular components in age-dependent tertiary lymphoid tissues of kidney and liver.

ABSTRACT: Tertiary lymphoid tissues (TLTs) are ectopic lymphoid structures induced by multiple stimuli, including infection and tissue injuries; however, their clinical relevance in disease progression has remained unclear. We demonstrated previously that TLTs develop in mouse and human kidneys with aging and can be a potential marker of kidney injury and prognosis, and therapeutic targets. In addition, we found that two types of unique lymphocytes that emerge with aging, senescence-associated T cells and age-associated B cells, are essential for TLT formation in the kidney. Although TLTs develop with aging in other organs as well, their cellular and molecular components, and clinical significance remain unclear. In the present study, we found that TLTs developed in the liver with aging, and that th

SUBMITTER: Toriu N 

PROVIDER: S-EPMC11867392 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature