Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment.

ABSTRACT: Recent advancements in sonodynamic therapy (SDT) for cancer treatment have highlighted the potential of enhancing reactive oxygen species (ROS) generation and improving therapeutic outcomes. This study introduces zinc oxide (ZnO) nanorods (NRs) in situ loaded with silver nanoparticles (ZnO@Ag NRs), designed to optimize ROS production under ultrasound irradiation and offer significant advantages in tumor specificity and biosafety. The transmission electron microscopy and elemental mapping confirmed the consistent size and monodispersed Ag nanoparticle for ZnO@Ag NR. Sonodynamic properties showed that ZnO@Ag NRs produce higher singlet oxygen and hydroxyl radicals under ultrasound. In vitro studies demonstrated excellent biocompatibility and enhanced cell-killing effects of ZnO@

SUBMITTER: Tao Y 

PROVIDER: S-EPMC11867527 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature