Investigation of <i>GSTP1</i> and <i>PTEN</i> gene polymorphisms and their association with susceptibility to colorectal cancer.

ABSTRACT:

Background

This study investigates the association of single nucleotide polymorphism in glutathione S transferase P1 (rs1695 and rs1138272) and phosphatase and TENsin homolog (rs701848 and rs2735343) with the risk of colorectal cancer (CRC).

Patients and methods

In this case-control study, 250 healthy controls and 200 CRC patients were enrolled. All subjects were divided into 3 groups: healthy control, patients, and overall (control + patients). Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The demographic information, including age, gender, location, smoking status, cancer stage, and node involvement, were collected.

Results

The allele frequencies of PTEN rs701848 in overall subjects were 0.78 for

SUBMITTER: Durr-E-Shahwar 

PROVIDER: S-EPMC11867568 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature