Contactless body temperature assessment for signalling humane endpoints in a mouse model of sepsis.

ABSTRACT: Minimising suffering is an ethical and legal requirement in animal research. This is particularly relevant for research on animal models of sepsis and septic shock, which show rapid progression towards severe stages and death. Specific and reliable criteria signalling non-recovery points can be used as humane endpoints, beyond which a study cannot be allowed to progress, thus preventing avoidable suffering. Body temperature is a key indicator for assessing animal health and welfare and has been suggested to have potential for monitoring the status of mouse models of sepsis. In this study, we monitored temperature variations using contactless methods - thermal imaging and subcutaneously implanted PIT tags - in a surgical model of sepsis by caecal ligation and puncture (CLP). We monitored bo

SUBMITTER: Miranda C 

PROVIDER: S-EPMC11867820 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature