Enabling electric field model of microscopically realistic brain.

ABSTRACT:

Background

Modeling brain stimulation at the microscopic scale may reveal new paradigms for various stimulation modalities.

Objective

We present the largest map to date of extracellular electric field distributions within a layer L2/L3 mouse primary visual cortex brain sample. This was enabled by the automated analysis of serial section electron microscopy images with improved handling of image defects, covering a volume of 250 × 140 × 90 μm³.

Methods

The map was obtained by applying a uniform brain stimulation electric field at three different polarizations and accurately computing microscopic field perturbations using the boundary element fast multipole method. We used the map to identify the effect of microscopic field perturbations on the activation thresholds of

SUBMITTER: Qi Z 

PROVIDER: S-EPMC11867869 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature