Cost-effectiveness analysis of sequential two-step screening versus direct colonoscopy screening for colorectal cancer: a large-scale survey in Eastern China.

ABSTRACT:

Objectives

Despite the implementation of colorectal cancer (CRC) screening programs in many regions worldwide over the past few decades, the cost-effectiveness of these programs has been questioned owing to their acceptance rates. In this study, we evaluated the cost-effectiveness of screening strategies, quantified the impact of colonoscopy acceptance rates, and analyzed the underlying factors driving individual preferences.

Methods

The cost-effectiveness of three strategies-no screening, sequential two-step screening (fecal immunochemical test and risk assessment, followed by colonoscopy), and colonoscopy screening-was evaluated from a societal perspective. This assessment was conducted using a decision-tree Markov model with the incremental cost-effectiveness ratio as the

SUBMITTER: Fu Y 

PROVIDER: S-EPMC11867945 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature