Intra- and inter-session reliability and repeatability of ¹H magnetic resonance spectroscopy for determining total creatine concentrations in multiple brain regions.

ABSTRACT: Using proton magnetic resonance spectroscopy (¹H MRS) to determine total creatine (tCr) concentrations will become increasingly prevalent, as the role of creatine (Cr) in supporting brain health gains interest. Methodological limitations and margins of error in repeated ¹H MRS, which often surpass reported effects of supplementation, permeate existing literature. We examined the intra- and inter-session reliability and repeatability of ¹H MRS for determining tCr concentrations across multiple brain regions (midbrain, visual cortex and frontal cortex). Eighteen healthy adults aged 20-32 years were recruited (50% female; n = 14 intra-session; n = 15 inter-session). ¹H Magnetic resonance imaging and spectroscopy were completed at 3 T. Intra-session

SUBMITTER: Pratt J 

PROVIDER: S-EPMC11868024 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature