Molecular epidemiology and genetic dynamics of carbapenem-resistant hypervirulent <i>Klebsiella pneumoniae</i> in China.

ABSTRACT: Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CRhvKP) poses a significant global health threat due to its enhanced virulence and resistance. This study analyzed 5,036 publicly available K. pneumoniae genomes from China (2005-2023), identifying 1,538 CRhvKP genomes, accounting for 44.6% of carbapenem-resistant isolates and 69.5% of hypervirulent isolates. Predominant carbapenemases included bla _KPC (92.1%), with an increasing prevalence of bla _NDM and bla _OXA-48-like genes. Most isolates (93.6%) carried both aerobactin and yersiniabactin genes. The genetic background showed high diversity, characterized by 36 sequence types (STs) and 22 capsule types, with high-risk endemic STs such as ST11, ST15, and ST23 being

SUBMITTER: Li X 

PROVIDER: S-EPMC11868059 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature