Specific gut microbiota and serum metabolite changes in patients with osteoarthritis.

ABSTRACT:

Introduction

Recent research indicated a strong link between the gut microbiota and osteoarthritis. However, the complex interplay between the gut microbiota, serum metabolites, and the progression of osteoarthritis in affected individuals remains largely unexplored. This study aimed to investigate the characteristics of the gut microbiota and serum metabolites in patients with osteoarthritis.

Methods

Participants with either healthy knees or osteoarthritis were enrolled and categorized into healthy control (HC) and osteoarthritis (OA) groups. Fecal and blood samples were collected for 16S rRNA gene sequencing, metabolomic analysis via liquid chromatography-mass spectrometry (LC-MS), and integrated evaluation.

Results

The results showed no significant variation in gut

SUBMITTER: Wang W 

PROVIDER: S-EPMC11868077 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature