Inducing hypertension in <i>Myh11</i> ^R247C/R247C mice triggers aortic dissections with increased focal adhesion kinase signaling.

ABSTRACT:

Objective

We sought to determine if hypertension in combination with a "variant of uncertain significance" that disrupts protein function, MYH11 p.Arg247Cys, would induce aortic dissections in a mouse model.

Approach and results

Administration of L-NAME via drinking water and a high salt diet increased blood pressure in WT and Myh11^R247C/R247C mice and triggered type A dissections with cardiac tamponade in 20% of the Myh11^R247C/R247C mice. Myh11^R247C/R247C aortas have aberrant smooth muscle contractile unit-elastin connections by transmission electron microscopy, along with increased focal adhesion signaling at baseline, which further increases with hypertension.

Conclusion

Gene-environment interactions trig

SUBMITTER: Kwartler CS 

PROVIDER: S-EPMC11868086 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature