CCR7A defines a subpopulation of IgD⁺IgM^- B cells with higher IgD secreting capacity in the rainbow trout skin.

ABSTRACT: B cells exclusively expressing IgD on the cell surface (IgD⁺IgM^- B cells) have been identified in mammals, where they seem to play a still not well-defined role in peripheral tolerance. These cells have also been reported in catfish (Ictalurus punctatus) peripheral blood and in several mucosal tissues of rainbow trout (Oncorhynchus mykiss), including gut, gills and skin. As in mammals, the precise function of these cells remains obscure, yet, in rainbow trout mucosal surfaces, these cells have been shown to be differentiated to plasma-like cells. Interestingly, in the gills, these IgD⁺IgM^- B cells expressed high levels of the CC chemokine receptor 7 (CCR7), receptor that in mammals controls the migration of B and T cells to secondar

SUBMITTER: Morel E 

PROVIDER: S-EPMC11868095 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature