Global burden and international disparities in NASH-associated liver Cancer: mortality trends (1990-2021) and future projections to 2045.

ABSTRACT:

Background

NASH-associated liver cancer (NALC) is a significant contributor to global cancer mortality, closely linked to the increasing prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). This study comprehensively examines the global burden of NALC from 1990 to 2021.

Methods

This study used data from the Global Burden of Disease (GBD) 2021 database to analyze NALC death and age-standardized death rates (ASDR) globally and regionally from 1990 to 2021. We applied Joinpoint regression analysis to assess temporal trends, calculating the annual percent change (APC) and average annual percent change (AAPC). Decomposition analysis was performed to break down mortality changes into contributions from population aging, growth, and epid

SUBMITTER: Nie Q 

PROVIDER: S-EPMC11868124 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature