Causal association of sarcopenia-related traits with brain cortical structure: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Patients with sarcopenia often experience cognitive decline, affecting cortical structures, but the causal link remains unclear. We used bidirectional Mendelian randomization (MR) to explore the relationship between sarcopenia-related traits and cortical structure.

Methods

We selected genetic variables from genome-wide association study data. Three different MR methods were used: inverse-variance weighted analysis, MR-Egger regression, and the weighted median test. For significant estimates, we further conducted Cochran's Q test, MR-Egger intercept test, leave-one-out analyses, and MR-PRESSO to assess heterogeneity.

Results

In forward MR analysis, appendicular lean mass (ALM) decreased the thickness (TH) of lateral occipital gyrus and increased the TH of pa

SUBMITTER: Zhan Y 

PROVIDER: S-EPMC11868162 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature