Comprehensive microRNA analyses using vitreous humor of ocular sarcoidosis.

ABSTRACT:

Purpose

MicroRNAs (miRNAs) are non-coding RNAs which have attracted attention as biomarkers in a variety of diseases. However, extensive unbiased analysis of miRNA in vitreous humor of sarcoidosis patients has not been reported. In the present study, we comprehensively analyzed the dysregulated miRNAs in ocular sarcoidosis to search for potential biomarkers.

Materials and methods

This study included seven patients diagnosed with ocular sarcoidosis (five definite and two presumed). Five patients with unclassified uveitis and 24 with non-inflammatory diseases served as controls. MicroRNA expression levels in vitreous humor samples were measured by microarray, and differentially expressed miRNAs between sarcoidosis and other diseases were explored. Next, pathway enrichment anal

SUBMITTER: Asakage M 

PROVIDER: S-EPMC11868165 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature