The predictive power of ¹⁸F-FDG PET/CT two-lesions radiomics and conventional models in classical Hodgkin's Lymphoma: a comparative retrospectively-validated study.

ABSTRACT: In a previous preliminary study, radiomic features from the largest and the hottest lesion in baseline ¹⁸F-FDG PET/CT (bPET/CT) of classical Hodgkin's Lymphoma (cHL) predicted early response-to-treatment and prognosis. Aim of this large retrospectively-validated study is to evaluate the predictive role of two-lesions radiomics in comparison with other clinical and conventional PET/CT models. cHL patients with bPET/CT between 2010 and 2020 were retrospectively included and randomized into training-validation sets. Target lesions were: Lesion_A, with largest axial diameter (D_max); Lesion_B, with highest SUV_max. Total-metabolic-tumor-volume (TMTV) was calculated and 212 radiomic features were extracted. PET/CT features were harmonized using ComBat across two s

SUBMITTER: Triumbari EKA 

PROVIDER: S-EPMC11868178 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature