Cerebral salt wasting syndrome as a probable cause of postoperative polyuria in patients with supratentorial Non-midline tumors: A prospective observational study with targeted and quantitative metabolomic approach.

ABSTRACT: Polyuria, or excessive fluid loss through the kidneys, is a common issue in neurocritical patients, often resulting from conditions such as fluid volume overload, osmotic diuretics, central diabetes insipidus (CDI), or cerebral salt wasting syndrome (CSWS). Notably, the specific cause of postoperative polyuria within 24 h in patients with tumors located in the supratentorial non-midline region remains poorly understood. To address this gap, we conducted a prospective observational study with 30 patients and found that eight (26.7%) experienced postoperative polyuria. Binary logistic regression analysis of clinical data ruled out fluid volume and osmotic diuretics as the underlying causes of postoperative polyuria, and suggested a very subtle association between tumor size and polyuria (OR 

SUBMITTER: Shi L 

PROVIDER: S-EPMC11868211 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature