Differences in Blood Eosinophil Level During Stable Disease and During Exacerbation of COPD and Exacerbation Risks.

ABSTRACT:

Background

Although blood eosinophil count (BEC) has been extensively studied as a biomarker in chronic obstructive pulmonary disease (COPD), there remain challenges and controversy in using a single reading. It has not been determined whether the difference in BEC between baseline and that during an acute exacerbation of COPD (AECOPD) has any role in predicting subsequent AECOPD.

Methods

A prospective study was conducted to investigate the possible role of differences in BEC from baseline to that during AECOPD to predict future AECOPD risk. The BEC difference was expressed as absolute eosinophil difference: BEC at index moderate-to-severe exacerbation (E_i) - baseline BEC (E₀).

Results

Among 348 Chinese patients with COPD, 158 who experienced an

SUBMITTER: Kwok WC 

PROVIDER: S-EPMC11868221 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature