Relationships of hematocrit concentration with dementia from a multiethnic population-based study.

ABSTRACT:

Objective

Red blood cell (RBC) concentration impacts cerebrovascular disease, yet it is unclear whether RBC concentrations relate to dementia risk, particularly in racially/ethnically diverse cohorts. We investigated whether RBC concentrations associate with incident dementia risk in a diverse population of stroke-free individuals and explored whether cerebral small vessel disease (CSVD) mediates this relationship.

Methods

A longitudinal observational analysis was performed using a population-based cohort of stroke-free, older adult participants (>50 years) from the Northern Manhattan Study (NOMAS) enrolled between 2003 and 2008. Participants received baseline hematocrit testing, MRI neuroimaging, and cognitive assessments at baseline and long-term follow-up. Associations of

SUBMITTER: Roh DJ 

PROVIDER: S-EPMC11868278 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature