Role of MLIP in burn-induced sepsis and insights into sepsis-associated cancer progression.

ABSTRACT:

Introduction

Burn-induced sepsis is a critical clinical challenge marked by systemic inflammation, immune dysregulation, and high mortality. Macrophage-driven inflammatory pathways are central to sepsis pathogenesis, while immune cell metabolic reprogramming plays a key role in both sepsis and cancer progression.

Methods

Bioinformatics analyses using GEO, TCGA, and GTEx datasets identified MLIP-modulated genes linked to immune responses and prognosis. In vitro, LPS-stimulated HUVEC cells were used to study MLIP's effects on inflammation and macrophage function through cell viability, ROS levels, cytokine expression, qRT-PCR, and immunofluorescence assays.

Results

MLIP-modulated genes were associated with immune-related metabolic pathways in both sepsis and canc

SUBMITTER: Li Z 

PROVIDER: S-EPMC11868298 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature