Uncovering two neutrophil-committed progenitors that immediately precede promyelocytes during human neutropoiesis.

ABSTRACT: Technological advances have greatly improved our knowledge of myelopoiesis, for example, with the discovery of granulocyte‒monocyte‒dendritic cell (DC) progenitors (GMDPs), monocyte‒DC progenitors (MDPs), common DC progenitors (CDPs) and common monocyte progenitors (cMoPs) on the basis of flow cytometry approaches. Concomitantly, some progress has been made in characterizing the very early phases of human neutropoiesis with the description of novel CD66b⁺ progenitors, including eNePs, PMs w/o eNePs, ProNeus, and PreNeus. More recently, we identified four SSC^loLin^-CD66b^-CD45^dimCD34⁺/CD34^dim/-CD64^dimCD115^- cells as the earliest precursors specifically committed to the neutrophil lineage present

SUBMITTER: Signoretto I 

PROVIDER: S-EPMC11868371 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature