Development of a novel postoperative adhesion induction model in cynomolgus monkeys with high reliability and reproducibility.

ABSTRACT: Postoperative adhesions frequently occur following abdominal surgical interventions, leading to serious morbidities and requiring new therapeutic strategies. The development of new therapeutic agents to reduce postoperative adhesions needs animal models that closely mirror human pathophysiology. In this study, we established a novel surgical adhesion model in cynomolgus monkeys, which are characteristically similar to humans. Our model reliably and reproducibly developed adhesions. Histopathological analyses revealed that monkeys undergoing our novel surgery method exhibited changes consistent with those in monkeys that underwent open abdominal surgery. Furthermore, the cellular components of the adhesion tissue in our monkey model reflected those reported in human adhesion tissue. Further

SUBMITTER: Nakagawa K 

PROVIDER: S-EPMC11868379 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature