NLRP3 overexpression exacerbated synovium tissue degeneration in juvenile collagen-induced arthritis.

ABSTRACT: Juvenile idiopathic arthritis (JIA) can lead to synovial inflammation. JIA is a chronic autoimmune inflammatory condition that primarily affects children. It is recognized as the most prevalent form of arthritis in the pediatric population and is associated with significant impairment and disability. As an inflammatory regulator, Nod-like receptor 3 (NLRP3) has been implicated in various autoimmune diseases. However, the specific mechanism by which NLRP3 impacts the progress of JIA remains unclear. Therefore, we conducted this study to investigate the specific mechanism of NLRP3 on the progress of synovial inflammation in juvenile collagen-induced arthritis (CIA). The CIA model was established using Sprague‒Dawley (SD) rats aged 2-3 weeks. In this study, we investigated the potential role

SUBMITTER: Khadour FA 

PROVIDER: S-EPMC11868420 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature