Insights from lipidomics into the terminal maturation of circulating human reticulocytes.

ABSTRACT: In the age of "omics", lipidomics of erythropoiesis is still missing. How reticulocytes mature in the circulation into functional erythrocytes is also largely unknown. We have isolated here two populations of human circulating reticulocytes at different levels of maturation, and three subpopulations of erythrocytes of different age, and characterized the evolution of their lipidome. (Sphingomyelin+cholesterol) and partly phosphatidylethanolamine increase relative to total lipids, whereas phosphatidylcholine and phosphatidylserine decrease from immature reticulocytes to mature erythrocytes, at the same time as the surface area per cell decreases. The relative amounts of more than 70 phospholipid subclasses, based on the number of carbon atoms (12-24) and of double bonds (0-6) in the fatty a

SUBMITTER: Minetti G 

PROVIDER: S-EPMC11868425 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature