Identification of immunogenic HLA-A*02:01 epitopes associated with HCC for immunotherapy development.

ABSTRACT:

Background

HCC is the most common form of primary liver cancer, and despite recent advances in cancer treatment, it remains associated with poor prognosis and a lack of response to conventional therapies. Immunotherapies have emerged as a promising approach for cancer treatment, especially through the identification of tumor-specific immunogenic epitopes that can trigger a targeted immune response. This study aimed to identify immunogenic epitopes associated with HCC for the development of specific immunotherapies.

Methods

We used high-throughput data screening and bioinformatics tools for antigens and epitope selection. The immunogenicity of the selected epitopes was studied after coculture of peripheral blood mononuclear cells obtained from healthy donors or HCC patients w

SUBMITTER: Maino A 

PROVIDER: S-EPMC11868434 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature