Assessment of Baseline Ultrawidefield Fluorescein Angiographic Quantitative Leakage Parameters with Ultrawidefield Fundus Features and Clinical Parameters in Diabetic Retinopathy in Protocol AA.

ABSTRACT:

Purpose

Evaluate quantitative leakage parameters on ultrawidefield fluorescein angiography (UWF-FA) images and explore their association with Diabetic Retinopathy Severity Scale (DRSS), predominantly peripheral lesions (PPLs), visual acuity, and clinical characteristics.

Design

A post hoc analysis of baseline UWF-FA images in the DRCR Retina Network observational study Protocol AA.

Participants

A total of 575 eyes from 384 adults across 38 sites in the United States and Canada with gradable UWF-FA.

Methods

A machine learning-enhanced feature extraction platform provided initial leakage segmentation of UWF-FA images sequentially reviewed and corrected by 2 certified readers for segmentation accuracy. Ultrawidefield fluorescein angiography leakage was measured in

SUBMITTER: Writing Committee for the DRCR Retina Network 

PROVIDER: S-EPMC11868455 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature