Magnetically reshapable 3D multi-electrode arrays of liquid metals for electrophysiological analysis of brain organoids.

ABSTRACT: To comprehend the volumetric neural connectivity of a brain organoid, it is crucial to monitor the spatiotemporal electrophysiological signals within the organoid, known as intra-organoid signals. However, previous methods risked damaging the three-dimensional (3D) cytoarchitecture of organoids, either through sectioning or inserting rigid needle-like electrodes. Also, the limited numbers of electrodes in fixed positions with non-adjustable electrode shapes were insufficient for examining the complex neural activity throughout the organoid. Herein, we present a magnetically reshapable 3D multi-electrode array (MEA) using direct printing of liquid metals for electrophysiological analysis of brain organoids. The adaptable distribution and the softness of these printed electrodes facilitate t

SUBMITTER: Kim E 

PROVIDER: S-EPMC11868496 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature