The association between metabolite concentrations and wellbeing in adults.

ABSTRACT: The biological complexity of wellbeing is studied from various perspectives, including genetics and epigenetics. However, there is a knowledge gap concerning other layers, such as metabolomics, which is dynamic and changes throughout life. This study explores the association between metabolites and wellbeing in a sample (N = 4748) drawn from the Netherlands Twin Register. A latent factor score for wellbeing was constructed based on: Quality of Life, Life Satisfaction, and Subjective Happiness. A total of 231 blood metabolites were analyzed using ¹HNMR technique. Linear regression models were performed for each metabolite, while correcting for family clustering, relevant covariates, and multiple testing. None of the metabolites were significantly associated with wellbeing after m

SUBMITTER: Azcona-Granada N 

PROVIDER: S-EPMC11868532 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature