Integrative systems biology framework discovers common gene regulatory signatures in mechanistically distinct inflammatory skin diseases.

ABSTRACT: More than 20% of the population across the world is affected by non-communicable inflammatory skin diseases including psoriasis, atopic dermatitis, hidradenitis suppurativa, rosacea, etc. Many of these chronic diseases are painful and debilitating with limited effective therapeutic interventions. This study aims to identify common regulatory pathways and master regulators that regulate the molecular pathogenesis of inflammatory skin diseases. We designed an integrative systems biology framework to identify the significant regulators across several diseases. Network analytics unraveled 55 high-value proteins as significant regulators in molecular pathogenesis which can serve as putative drug targets for more effective treatments. We identified IKZF1 as a shared master regulator in hidradeni

SUBMITTER: Mishra B 

PROVIDER: S-EPMC11868562 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature