Lupus and inflammatory bowel disease share a common set of microbiome features distinct from other autoimmune disorders.

ABSTRACT:

Objectives

This study aims to elucidate the microbial signatures associated with autoimmune diseases, particularly systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), compared with colorectal cancer (CRC), to identify unique biomarkers and shared microbial mechanisms that could inform specific treatment protocols.

Methods

We analysed metagenomic datasets from patient cohorts with six autoimmune conditions-SLE, IBD, multiple sclerosis, myasthenia gravis, Graves' disease and ankylosing spondylitis-contrasting these with CRC metagenomes to delineate disease-specific microbial profiles. The study focused on identifying predictive biomarkers from species profiles and functional genes, integrating protein-protein interaction analyses to explore effector-like p

SUBMITTER: Zhou H 

PROVIDER: S-EPMC11868722 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature