Allium Macrostemon Bge. Attenuates the Cognitive Decline of Aging Mice by Enhancing BDNF/TrkB Pathway.

ABSTRACT: Allium macrostemon Bge. (AM) is a widely utilized culinary spice recognized for its numerous health-promoting properties. Aging-related cognitive impairment (ARCI) represents a significant global health concern during the aging process. However, the potential of AM to attenuate ARCI has not been investigated. This work aims to reveal the effects and potential mechanisms of the water extraction of AM (WEAM) in alleviating ARCI, with a particular emphasis on the BDNF/TrkB signaling pathway. The findings showed a significant enhancement in memory function and a reduction in hippocampal neuronal damage in aging mice following treatment with WEAM, manifested by an increased spontaneous alternation rate in the Y-maze, prolonged step-through latency, and decreased number of errors in the P

SUBMITTER: Sheng R 

PROVIDER: S-EPMC11868736 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature