Assessing Traditional Chinese Medicines for Anti-Dengue Using a National Health Insurance Research Database and Bioassays.

ABSTRACT: Dengue fever is a widespread viral infectious disease transmitted by mosquitoes. Despite the potentially fatal consequences for some individuals, no antiviral drugs have been approved for the treatment of this disease. Taiwan's National Health Insurance Database (NHID) holds extensive medical records for almost every resident, encompassing conventional and traditional Chinese medicine (TCM) treatments. This study aims to uncover potential TCM formulas with antiviral properties against dengue fever by analyzing NHID data. Initially, the NHID was screened to identify candidate TCM formulas. Subsequently, immunofluorescence assays were conducted to evaluate the anti-dengue virus (DENV) effects of these TCM compounds. Selected TCM formulas underwent testing for cytotoxicity and anti-DENV activ

SUBMITTER: Su WY 

PROVIDER: S-EPMC11868784 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature