Altered Effective Connectivity During Threat Anticipation in Individuals With Alcohol Use Disorder.

ABSTRACT:

Background

A developing theory and recent research suggest that heightened reactivity to uncertain stressors or threats may be an important individual difference factor that facilitates excessive drinking as a means of avoidance-based coping and characterizes individuals with current and past alcohol use disorder (AUD). Neuroimaging studies of unpredictable threat processing have repeatedly demonstrated activation of the anterior insula, anteromedial thalamus, and dorsal anterior cingulate cortex. In the current study, we aimed to understand how these 3 regions function as a network during anticipation of unpredictable threat (and predictable threat).

Methods

Participants were 43 adults (ages 21-30) with AUD and 26 healthy control participants. Functional magnetic resonance

SUBMITTER: Radoman M 

PROVIDER: S-EPMC11868811 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature