Quasi-Diffusion Imaging: Application to Ultra-High b-Value and Time-Dependent Diffusion Images of Brain Tissue.

ABSTRACT: We demonstrate that quasi-diffusion imaging (QDI) is a signal representation that extends towards the negative power law regime. We evaluate QDI for in vivo human and ex vivo fixed rat brain tissue across b $$ b $$ -value ranges from 0 to 25,000 s mm^-2, determine whether accurate parameter estimates can be acquired from clinically feasible scan times and investigate their diffusion time-dependence. Several mathematical properties of the QDI representation are presented. QDI describes diffusion magnetic resonance imaging (dMRI) signal attenuation by two fitting parameters within a Mittag-Leffler function (MLF). We present its asymptotic properties at low and high b $$ b $$ -values and define the inflection point (IP) above which the signal tends to a negative power law. To sh

SUBMITTER: Barrick TR 

PROVIDER: S-EPMC11868825 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature