Reversible redox ¹⁹F magnetic resonance imaging nanoprobes for monitoring the redox state <i>in vivo</i>.

ABSTRACT: Redox processes are indispensable for physiology, and dysregulated redox balance is critical in various metabolic diseases. The development of imaging diagnosis tools for real-time monitoring of the redox state in vivo is of great importance yet highly challenging. Here, we designed trifluoromethyl (-CF₃) grafted selenide polymer nanoprobes for reversible redox sensing in vivo. Based on the reversible shift of the ¹⁹F-nuclear magnetic resonance (NMR) peak between oxidation and reduction states of the nanoprobes exposed to different redox species, the ¹⁹F-magnetic resonance imaging (MRI) signal ratio of S _Ox/(S _Ox + S _Red) was successfully applied to monitor the redox state in a tumor. These

SUBMITTER: Xiong X 

PROVIDER: S-EPMC11868907 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature