Selective dual-mode detection of reactive oxygen species and metal ions by chemodosimetric vs. chelation pathways: fluorescence 'turn-on' with OCl^- and Zn²⁺/Mn²⁺, employing theoretical, practical, and bioimaging applications.

ABSTRACT: An indole-coupled diaminomaleonitrile-based fluorescent chemosensor IMA has been designed and developed for the selective detection of ROS (OCl^-) and metal ions Zn²⁺ and Mn²⁺ via chemodosimetric and chelation pathways respectively. The selective sensing of OCl^- is induced by a method of oxidatively cleaving of the imine bond of IMA, forming free indole aldehyde, which results in a 21-fold enhancement of fluorescence at 521 nm, with a detection limit of 2.8 µM. On the other hand, the selective binding of IMA with Zn²⁺ and Mn²⁺ results in chelation-induced enhanced fluorescence (CHEF) and increased intermolecular charge transfer (ICT), leading to a 4-fold and 3-fold fluorescence enhancement at 432 nm and 435 nm, with th

SUBMITTER: Kumar MS 

PROVIDER: S-EPMC11869208 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature