Global, regional, and national burden of cardiovascular disease attributable to kidney dysfunction (1990-2021) with projections to 2050: analysis of the 2021 Global Burden of Disease study.

ABSTRACT:

Aims

This study examines global trends in cardiovascular disease (CVD) associated with kidney dysfunction (KD) from 1990 to 2021 and projects future trends through 2050.

Methods

This study analyzed the 2021 Global Burden of Disease (GBD) database, focusing on age-standardized mortality rate (ASMR), age-standardized disability-adjusted life years rate (ASDR), absolute numbers, estimated annual percentage change, and average annual percent change. A Bayesian age-period-cohort model was employed to project global trends from 2022 to 2050. Variables included age, gender, national levels, and Socio-demographic Index (SDI) regions.

Results

From 1990 to 2021, the CVD burden from KD increased, with deaths rising from 1,312,393 to 2,095,800 and DALYs from 27,382,767 to 41,589,

SUBMITTER: Zhang T 

PROVIDER: S-EPMC11869346 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature