Prognostic significance of systemic immune inflammation index for ovarian cancer: An updated systematic review and meta-analysis.

ABSTRACT:

Objective

Several inflammatory indices have been used to assess the prognosis of ovarian cancer, with variable results. This review assessed whether the systemic immune inflammation index (SII) can predict outcomes in patients with ovarian cancer.

Methods

Embase, PubMed, CENTRAL, Web of Science, and Scopus databases were searched by the two reviewers from inception to 15th October 2024 for studies assessing the relationship between SII and overall survival (OS) or disease-free survival (DFS).

Results

Ten studies with eleven cohorts were included. Pooled analysis showed that higher SII was a significant predictor of poor OS (HR: 2.35 95% CI: 1.56, 3.55 I² = 88%) and worse DFS (HR: 2.51 95% CI: 1.71, 3.67 I² = 80%) after ovarian cancer. Sensitivity

SUBMITTER: Chu B 

PROVIDER: S-EPMC11869409 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature