Whole genome characterization of feline coronaviruses in Thailand: evidence of genetic recombination and mutation M1058L in pathotype switch.

ABSTRACT: Feline coronavirus (FCoV) is a significant pathogen that infects the feline population worldwide. FCoV can cause mild enteric disease and a fatal systemic disease called feline infectious peritonitis (FIP). In this study, a cross-sectional survey of FCoV in domestic cats from small animal hospitals in Thailand was conducted from January to December 2021. Our result showed that out of 238 samples tested for FCoV using 3' UTR-specific RT-PCR, 18.7% (28/150) of asymptomatic cats and 25.5% (12/47) of cats with unknown status tested positive for FCoVs. Additionally, 51.2% (21/41) of cats with suspected FIP were found to be positive for FCoVs. Genotype identification using S gene-specific RT-PCR showed that all FCoV-positive samples (n = 61) were FCoV type I. This study obtained the whole genome

SUBMITTER: Phyu EM 

PROVIDER: S-EPMC11869453 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature