T1/T2 mapping as a non-invasive method for evaluating liver fibrosis based on correlation of biomarkers: a preclinical study.

ABSTRACT:

Background

Given the inherent limitations of invasive biopsy and the insufficient accuracy of liver-related serum biomarkers, there is an urgent need for the development of reliable, non-invasive imaging techniques for the diagnosis of liver fibrosis. This study aims to investigate the correlation between magnetic resonance imaging (MRI) T1/T2 mapping sequences and biomarkers of collagen deposition and ongoing systemic inflammation, and to evaluate the potential of T1/T2 mapping as a non-invasive method for the accurate diagnosis of liver fibrosis.

Methods

A mouse model of carbon tetrachloride (CCl₄)-induced liver fibrosis was established and T1/T2 mapping were performed at different weeks of treatment. The histopathological analysis, collagen quantification, and

SUBMITTER: Xue S 

PROVIDER: S-EPMC11869460 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature