Genome mining and metabolite profiling illuminate the taxonomy status and the cytotoxic activity of a mangrove-derived Microbacterium alkaliflavum sp. nov.

ABSTRACT: The genus Microbacterium in the phylum Actinomycetota contains over 100 species to date that little is known about their bioactive metabolites production. In this study, a mangrove sediment-derived strain B2969^T was identified as a novel type strain within the genus Microbacterium due to the low 16S rRNA gene sequence similarity (< 99%), and low overall genome relatedness indices (ANI, 75.4%-79.5%; dDDH, 18.5%-22.7%, AAI, 68.7%-76.3%; POCP, 48.3%-65.0%) with the validly named species of the genus. The type strain B2969^T (= MCCC 1K099113^T = JCM 36707 ^T) is proposed to represent Microbacterium alkaliflavum sp. nov.. The crude extracts of strain B2969^T showed weak cytotoxicity against NPC cell lines TW03 and 5-8F, with IC₅₀ val

SUBMITTER: Hu WJ 

PROVIDER: S-EPMC11869465 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature