Reduction of subclinical acute cardiac injury through DIBH radiotherapy: a single-institution real-world clinical cohort analysis.

ABSTRACT:

Background

Radiotherapy for left-sided breast cancer is associated with additional cardiac risks. Deep inspiration breath hold (DIBH) has emerged as the primary cardiac sparing technique, demonstrating significant reduction in mean heart dose (MHD) and left anterior descending coronary artery (LAD) dose. However, the issue of whether dosimetric advantages can be effectively translated into clinically measurable benefits for patients remains to be further elucidated. The study aims to investigate whether DIBH, in contrast to free breathing (FB), could yield a clinical cardiac advantage, beyond dosimetry benefits, for patients with early left breast cancer following breast-conserving surgery combined with whole breast radiotherapy.

Patients and methods

The study involved 78 pa

SUBMITTER: Zhang K 

PROVIDER: S-EPMC11869486 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature