Causal association between non-thyroidal autoimmune diseases and Graves' ophthalmopathy: A mendelian randomization study.

ABSTRACT:

Purpose

This Mendelian randomization (MR) analysis study aimed to investigate the genetic causal relationship between non-thyroidal autoimmune diseases (ADs) and Graves' ophthalmopathy (GO).

Materials

Single nucleotide polymorphisms (SNPs) associated with inflammatory bowel disease (IBD), multiple sclerosis (MS), psoriasis vulgaris (PV), type 1 diabetes (T1D), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA) were obtained from the IEU Open genome-wide association studies (GWAS) database, GWAS data for GO were obtained from the FinnGen database. Bidirectional MR analysis was conducted using inverse variance weighted (IVW) method, weighted median (WM) method and MR-Egger test. Cochran's Q statistic was used to assess the heterogeneity between SNP estimates. MR

SUBMITTER: Ma L 

PROVIDER: S-EPMC11869498 | biostudies-literature | 2025 Feb-Mar

REPOSITORIES: biostudies-literature