MicroRNA-541-3p/Rac2 signaling bridges radiation-induced lung injury and repair.

ABSTRACT:

Background

While radiation-induced lung injury decreases quality of life and suppresses efficacy of radiotherapy, to date, the relationship between radiation-induced lung injury and repair remains unclear. Our previous studies revealed that TNFRSF10B-RIPK1/RIPK3-MLKL signaling induces necroptosis of alveolar epithelial cells and potentiates radiation-induced lung injury. We also found that microRNA-541-3p is differentially expressed in radiation-damaged lungs. The connection between microRNA-541-3p, TNFRSF10B signaling, and TGFβ1 signaling is also unclear.

Objective

This study was performed to explore the regulatory effects of microRNA-541-3p on TNFRSF10B and TGFβ1 signaling.

Methods

Mouse alveolar epithelial cells were transfected with a vector expressing microRNA-54

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11869541 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature