Myelin-reactive CD8⁺ T cells influence conventional dendritic cell subsets towards a mature and regulatory phenotype in experimental autoimmune encephalomyelitis.

ABSTRACT: Multiple sclerosis (MS), an autoimmune demyelinating disease of the central nervous system, is modeled in mice as experimental autoimmune encephalomyelitis (EAE). While CD4⁺ T cells, primarily Th1 and Th17 subsets, drive disease pathogenesis, the exact function of CD8⁺ T cells remains unclear. We previously demonstrated that adoptively transferred myelin-reactive CD8⁺ T cells (PLP-CD8) prevent EAE induction and suppress ongoing disease through the engagement of MHC Class-I in recipient mice. Here, we show that PLP-CD8 induce regulatory changes in both subsets of conventional dendritic cells (cDC1 and CD11b⁺ cDC) in vivo and in vitro. Adoptively transferred PLP-CD8 promoted both cDC subsets to adopt a mature and regulatory phenotype with an anti-i

SUBMITTER: Upadhye M 

PROVIDER: S-EPMC11869544 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature