BMP9 enhances osteogenic differentiation in rheumatoid arthritis: a potential therapeutic approach.

ABSTRACT:

Objective

Rheumatoid arthritis (RA) is a chronic inflammatory disorder that causes joint damage, including cartilage degradation and bone erosion. Bone morphogenetic protein 9 (BMP9), a member of the TGF-β superfamily, plays a key role in osteogenesis and tissue repair. However, its role in bone erosion and inflammation in RA remains underexplored. This study aims to evaluate BMP9's therapeutic potential in RA, focusing on its effects on bone destruction, osteogenesis, and inflammation.

Materials and methods

In this study, BMP9 expression was analyzed in synovial tissues from RA and osteoarthritis patients and in the ankle joints of collagen-induced arthritis (CIA) mice using immunohistochemistry, qRT-PCR, and Western blotting. The therapeutic effect of BMP9 on bone destruct

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11869551 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature